HCP Case Studies
CPAP-Intolerant Professional Achieves Restful Sleep
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A CPAP-intolerant professional with moderate obstructive sleep apnea achieved meaningful clinical improvement following iNAP oral negative-pressure therapy. Treatment resulted in sustained nightly adherence, reduced apnea severity, improved daytime alertness, and enhanced sleep continuity. This real-world case highlights iNAP’s potential as a comfortable, mask-free alternative for patients unable to tolerate CPAP.
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CPAP-Intolerant Professional Achieves Restful Sleep
Oral Pressure Therapy (OPT) in Obstructive Sleep Apnea
MRI-based evaluation of OPT demonstrated significant anatomical airway changes in obstructive sleep apnea responders. OPT enlarged the retropalatal airway through anterior displacement of the soft palate, resulting in marked apnea–hypopnea index reduction. These mechanistic findings support OPT as a targeted, anatomy-driven alternative for selected patient's intolerant of CPAP.
Feb 3, 2026
Successful OSA Symptom Control - iNAP
Mandibular advancement oral appliance therapy provided effective symptom control in a CPAP-intolerant obstructive sleep apnea patient. Clinical evidence shows meaningful reductions in apnea severity, improved daytime symptoms, and high long-term adherence. Despite less AHI reduction than CPAP, superior nightly usage supports oral appliances as a practical alternative for selected OSA patients.
Feb 3, 2026
Single-Night Feasibility Study of Mask-Free Therapy
A single-night feasibility study evaluated mask-free intraoral negative-pressure therapy in obstructive sleep apnea patient's intolerant to CPAP. Results demonstrated significant reductions in apnea–hypopnea index, improved oxygenation, and enhanced sleep continuity. Rapid polysomnography-based assessment enabled early responder identification, supporting oral negative-pressure therapy as a practical, non-invasive alternative for selected patients.
Jan 7, 2026