15 articles
MRI-based evaluation of OPT demonstrated significant anatomical airway changes in obstructive sleep apnea responders. OPT enlarged the retropalatal airway through anterior displacement of the soft palate, resulting in marked apnea–hypopnea index reduction. These mechanistic findings support OPT as a targeted, anatomy-driven alternative for selected patient's intolerant of CPAP.
Feb 3, 2026
Mandibular advancement oral appliance therapy provided effective symptom control in a CPAP-intolerant obstructive sleep apnea patient. Clinical evidence shows meaningful reductions in apnea severity, improved daytime symptoms, and high long-term adherence. Despite less AHI reduction than CPAP, superior nightly usage supports oral appliances as a practical alternative for selected OSA patients.
Feb 3, 2026
A single-night feasibility study evaluated mask-free intraoral negative-pressure therapy in obstructive sleep apnea patient's intolerant to CPAP. Results demonstrated significant reductions in apnea–hypopnea index, improved oxygenation, and enhanced sleep continuity. Rapid polysomnography-based assessment enabled early responder identification, supporting oral negative-pressure therapy as a practical, non-invasive alternative for selected patients.
Jan 7, 2026
A middle-aged man with moderate obstructive sleep apnea demonstrated clinically meaningful improvement following iNAP therapy. After two months of nightly use, apnea–hypopnea index and arousal burden decreased significantly, accompanied by marked improvement in daytime sleepiness. This case highlights iNAP as a potential non-invasive alternative for selected patient's intolerant to CPAP.
Jan 7, 2026
Intraoral negative-pressure therapy with the iNAP Lite system demonstrated modest but significant improvement in mild-to-moderate obstructive sleep apnea–hypopnea syndrome. Mean apnea–hypopnea index decreased by approximately 26% on the first treatment night, with improved sleep continuity and good tolerability, supporting iNAP as a practical non-CPAP alternative for selected patients.
Jan 7, 2026
A clinical study evaluated airflow phenotyping using standard polysomnographic signals to predict oral appliance therapy outcomes in obstructive sleep apnea. Airflow characteristics, including event depth and expiratory pinching, accurately differentiated responders from non-responders with 74% classification accuracy, supporting personalized treatment selection and reducing ineffective therapy trials.
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